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姓名：鄭宜肪 |
職稱：副教授 |
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電話分機：3543 |
辦公室：K315-2
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E-Mail：ifcheng@stust.edu.tw |
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實驗室：K313
生物微流體晶片與生醫檢測系統實驗室 |
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最高學歷：國立成功大學 奈米科技暨微系統工程研究所 博士 |
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研究領域：生醫微流體晶片、生醫微機電、微奈米電動力學、生物感測器、研發成果商品轉化 |
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學術榮譽 |
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（1） 獲第七屆國家新創獎，一種新穎機制用於增加DNA快速雜交之靈敏度與選擇度，鄭宜肪、鐘政哲、陳盈廷、張憲彰。
（2） 獲第八屆國家新創獎，快速與簡易的細菌之藥敏分析晶片，鍾政哲、鄭宜肪、陳盈廷、張憲彰。
（3） 獲第九屆國家新創獎，一種血液中稀少致病菌的快速鑑定技術(<5 min)，鄭宜肪、林育德、楊富量。
（4） 獲第 十五屆國家新創獎，微流體光電整合敗血症快速診斷平台，謝文馨、趙文震、鄭宜肪、曾銘仁、張國恩、李訓源、李彥昌、賴俞杏。
（5） 獲第 十六屆國家新創獎續獎，微流體光電整合敗血症快速診斷平台，謝文馨、趙文震、鄭宜肪、曾銘仁、張國恩、李訓源、李彥昌、賴俞杏。
（6） 指導學生呂榮吉以"以電場促進奈米團聚之微生物快速鑑定晶片"之研究獲奈米科技創意實作競賽佳作。
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期刊論文 |
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1.
E Iswardy, T-C Tsai, I-F
Cheng, T-C Ho, G-C Perng, H-C Chang, A bead-based
immunofluorescence-assay on a microfluidic dielectrophoresis platform for
rapid dengue virus detection, Biosens. Bioelectron., 95,
174-181 (2017).
(SCI, IF= 11.44, Ranking: 1/28= 3.5%) (Cited by 61 times) 2. I-F Cheng*, T-Y Chen, and W-C Chao, Increasing
Local Density of Molecules/Bacteria on a Sensing Surface from Diluted Blood
Using 3D Hybrid Electrokinetics, Biomicrofluidics, 10, 034116
(2016) (SCI, IF= 3.258, Ranking: 3/31= 9.6%) (Cited by 8
times) 3. I-F Cheng*, W-L Huang,
T-Y Chen, Y-D Lin, C-W Liu, W-C Su*, Antibody-Free Isolation of Rare Cancer
Cells from Blood based on 3D Lateral Dielectrophoresis, Lab Chip, 15,
2950 (2015). (SCI,
IF= 6.97, Ranking:
6/79= 7.5 %) (Cited
by 94 times) (This work was selected for
publication as a Back Cover in Lab Chip) 4. I-F Cheng*, T-Y Chen,
R-J Lu and H-W Wu, Rapid Identification of Bacteria Utilizing Amplified
Dielectrophoretic Force-Assisted Nanoparticle-Induced SERS, Nanoscale Res
Lett, 9, 324 (2014).
(SCI, IF= 4.91, Ranking: 24 /143=
16.7 %)
(Cited by 52 times) 5. I-F Cheng, S-C Chiang,
C-C Chung, T-M Yeh, H-C Chang, Ripple Structure-Generated Hybrid
Eelectrokinetics for on-Chip Mixing and Separating of Functionalized Beads, Biomicrofluidics,
8, 061102
(2014).
(SCI, IF= 3.258, Ranking: 3/31=
9.6%)
(Cited by 9 times) 6. I-F
Cheng*, H-C Chang, T-Y Chen, CM Hu, F-L Yang, Rapid (<5min)
Identification of Pathogen in Human Blood by Electrokinetic Concentration and
Surface-Enhanced Raman Spectroscopy, Scientific Reports(Nature
Publishing Group), 3, 2365 (2013)
(SCI, IF= 5.708, Ranking: 5/56=
8.9%)
(Cited by 154 times) 7. I-F
Cheng, S-L Yang, C-C Chung, H-C Chang, A
Rapid Electrochemical Biosensor based on an AC Electrokinetics Enhanced
Immuno-reaction, Analyst, 138, 4656 (2013)
(SCI, IF= 4.616, Ranking: 7/74= 9.4%)
(Cited by 36 times) 8. I-F Cheng, H-W Han, H-C
Chang, Dielectrophoresis and shear enhanced DNA hybridization for rapid
discrimination of Candida species, Biosens. Bioelectron., 33,
36 (2012) (SCI, IF=
11.44, Ranking:
1/28= 3.5%, 3/74= 4%) 9. C-C Chung, I-F Cheng,
H-C Kan, H-M Chen, W-H Yang, H-C Chang, Screening of the antibiotic
susceptibility to ��-lactam-induced elongation of Gram-negative bacteria based
on dielectrophoresis, Anal. Chem., 84, 3347(2012). (SCI, IF= 6.986, Ranking: 4/74= 5%) (Cited by 48 times) 10. I-F Cheng, S-L Liu,
C-C Chung, H-C Chang, Stepwise gray-scale light-induced electric field
gradient for passive and continuous separation of microparticles, Microfluid
Nanofluid, 12, 95 (2012).
(SCI, IF=
2.529, Ranking: 7/56= 12.5%) (Cited by 8 times) 11. S-H Liao†, I-F Cheng†
and H-C Chang, Precisely sized separation of multiple
particles based on dielectrophoresis gradient in the z-direction,
Microfluid Nanofluid, 12, 201 (2012) (†Equal contribution)
(SCI, IF= 2.529, Ranking: 7/56= 12.5%) (Cited by 14 times)
12. I-F Cheng, C-C Chung and H-C Chang, High-throughput
electrokinetic bioparticle Focusing based on a travelling-wave
dielectrophoretic field, Microfluid Nanofluid, 10, 649 (2011).
(SCI, IF= 2.529,
Ranking: 7/56= 12.5%) (Cited by 36
times) 13. C-C Chung, I-F
Cheng, C-C Lin, and
H-C
Chang, Rapid quantification of bio-particles
based on image visualisation in a dielectrophoretic microfluidic chip, Microfluid Nanofluid, 10,
311 (2011).
(SCI, IF= 2.529, Ranking: 7/56= 12.5%) (Cited by 14 times) 14.
I-F Cheng, C-C Lin, D-Y Lin, H-C Chang, A dielectrophoretic chip with a
roughened metal surface for on-chip Surface Raman Enhanced Scattering
analysis of bacteria, Biomicrofluidics, 4,
034104 (2010).
(SCI, IF= 3.258, Ranking: 3/31=
9.6%) (Cited by 94
times) This work was
also selected for publication in Virtual
Journal of Biological Physics research, Sep. 15 (2010). 15. I-F Cheng, S Senapati,
X Cheng, S Basuray, H-C Chang and H-C Chang, A rapid
field-use assay for mismatch number and location of hybridized DNAs, Lab
Chip, 10, 828 (2010). (SCI, IF=
6.97, Ranking: 6/79= 7.5 %) (Cited
by 76 times) 16. I-F Cheng, V Froude,
Y-E Zhu, H-C Chang and H-C Chang, "A Continuous high throughput
bioparticle sorter based on 3D traveling wave dielectrophoresis", Lab Chip, 9,
3193 (2009). (SCI, IF= 6.97, Ranking: 6/79= 7.5 %) (Cited by 163
times) 17. I-F Cheng, H-C Chang, D Hou, and H-C Chang, "An integrated
dielectrophoretic chip for continuous bioparticle filtering, focusing,
trapping and detecting", Biomicrofluidics,
1, 021503 (2007). (SCI,
IF= 3.258, Ranking: 3/31= 9.6%) (Cited by 311 times, most cited
paper in Biomicrofluidics from 2007 to 2015) |
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國內期刊論文 |
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專利 |
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1.
Photoelectrical
device for concentration detection, method for concentration detection
thereof and method for testing an antibiotic susceptibility on bacteria, I-Fang Cheng , I-L Chen, T-Y
Chen, US patent, Patent NO.: US 11,143,585 B2, 2021-2039.。 2. 一種用於濃度檢測的光電裝置及其濃度檢測方法以及測試藥物對細菌有效性的方法，發明人: 鄭宜肪、陳姿穎、陳以靈，中華民國專利，專利證號: I685656，2020-2038。 3.
分離粒子之方法、其流道裝置以及捕捉結構，發明人: 鄭宜肪、蘇五洲、黃偉倫、陳姿穎、林育德，中華民國專利，專利證號: I524930, 2016-2033。 4. ‘Bio-Chip and Method for Separating and
Concentrating Particles Using the Same,’, I-Fang Cheng,
Hsien-Chang Chang, Fu-Liang Yang, Tzu-Ying Chen, US Patent, US 9,498,784 B2,
2016-2035. 5. 以複合電動力捕捉並分析生物微粒的方法與晶片，發明人: 鄭宜肪、張憲彰、蘇五洲、黃偉倫，中華民國專利，專利證號: I494563, 2015-2033. 6.
可選擇地濃縮分離待測粒子的方法與晶片，發明人: 鄭宜肪、楊富量、張憲彰、陳姿穎，中華民國專利，專利證號: I510773 , 2015-2032. 7. 生物晶片裝置及分離並濃縮一流體中的微粒的方法，發明人: 鄭宜肪、楊富量、張憲彰、陳姿穎，中華民國專利，專利證號: I472756, 2015-2032. 8. 介電微粒操控晶片與其製造方法和操控介電微粒的方法,發明人: 張憲彰、鍾政哲、鄭宜肪、王竣宏、蔣盛泉、任麗青，專利證號: I507803，2015-2033。 9. 鑑定微生物之晶片及方法，專利證號：I476397，2014-2031。 10. Method for Antibiotic Susceptibility Testing
and Determining Minimum Inhibitory Concentration of the Antibiotics,
Cheng-Che Chung, I-Fang Cheng,
Hsien-Chang Chang, US Patent, US 8,911,605 B2, 2014. 11. Microbial Identification and Manipulation of
Nanoscale Biomolecules, I-Fang Cheng, Hsien-Chang Chang,
Cheng-Che Chung, US Patent, US 8,808,518, 2014-2034. 12. 生物鑑定方法與操控奈米等級之生物分子的方法，發明人：鄭宜肪、張憲彰、鍾政哲，中華民國專利，專利證號: I404802 , 2013~2030. 13. 微生物抗藥性與抗生素最小抑制濃度之檢測方法”，發明人：鍾政哲、鄭宜肪、楊文宏、張憲彰，中華民國專利，專利證號: I532840, 2016-2031. 14. 用於微流體晶片之微粒定量方法，發明人: 鍾政哲、鄭宜肪、林其昌、張長泉、張憲彰, 中華民國專利，專利證號: I429906，2011-2027. 15. 具拉曼光譜增顯功能之微流體晶片，發明人: 鄭宜肪，張憲彰，林其昌，楊穎玫，張長泉，鍾政哲，中華民國專利，專利證號: I393883,
2011-2028. 16. “具捕捉濃縮功能之介電泳晶片”，發明人: 鄭宜肪，張憲彰，張長泉，林其昌，中華民國專利，專利證號: I331215，2010~2027. 17. “立體式介電泳晶片與其製造方法”，發明人: 張憲彰，鄭宜肪，張長泉，陳昭宏，中華民國專利，ROC，專利證號: I274159， 2007~2025. |
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研究計畫 |
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國科會計畫: 2022/1/1~2023/5/31 開發分析敗血症致病菌藥敏性的臨床檢測儀(II) (產業前瞻技術計畫案), (9,800,000元), PI 2022/8/1~2023/7/31 跨尺度、大面積奈米結構的高分子成型技術開發與其生醫及光學工程應用(1/3), (6,000,000元), Co-PI 2020/8/1~2022/10/31 更快速的臨床敗血症精準醫療之生物晶片檢測系統之開發, (2,469,000元), PI 2020/11/1~2021/11/30 開發分析敗血症致病菌藥敏性的臨床檢測儀(I) (產業前瞻技術計畫案), (9,200,000元), PI 2020/5/1~2021/4/30 免標定、快速、高靈敏光微流體生物感測系統於敗血症患者病原與宿主反應之快速同步偵測 (醫療器材創新研究計畫), (4,488,000元), Co-PI. 2019/8/1~2020/7/31 開發快速高靈敏低成本的細菌定量、藥敏分析與檢測體細胞數之生物晶片系統, (991,000元), PI 2019/5/1~2020/4/30 免標定、快速、高靈敏光微流體生物感測系統於敗血症患者病原與宿主反應之快速同步偵測 (3/3), (6,303,000元), Co-PI. 2018/5/1~2019/4/30 免標定、快速、高靈敏光微流體生物感測系統於敗血症患者病原與宿主反應之快速同步偵測 (2/3), (6,540,000元), Co-PI. 2018/8/1~2019/7/31 可快速進行乳房炎檢測、細菌藥敏分析與生乳品質監控的生物微流體晶片與其可攜式雛型機之開發, (1,136,000元), PI 2017/5/1-2018/4/30 免標定、快速、高靈敏光微流體生物感測系統於敗血症患者病原與宿主反應之快速同步偵測 (1/3), (6,873,000元), Co-PI. 2016/8/1~2018/10/31 三小時內同時鑑定、定量血液中致病菌與判知細菌抗藥性的通用型微流體生物晶片 (優秀年輕學者研究計畫), (2,423,000元), PI. 2015/8/1 ~2017/7/31 開發免抗體式循環腫瘤細胞純化與分析系統應用於肺癌的早期診斷、治療監控與預後追蹤,(1,690,000元), PI. 2013/8/1 ~2015/7/31 以交流電動力為基礎發展可分選與捕捉癌細胞並進行藥物作用判知的微分析系統(優秀年輕學者研究計
畫), (1,861,000元), PI. 2012/8/01 ~2013/8/31 以交流電動力結合表面增顯拉曼光譜進行血液中致病菌的快速鑑定, (686,000元), PI. 產學合作研究計畫: 2022/12/20~2024/12/19 Advanced BioMed. Inc, 微流體生物晶片研製、生物樣本實測與試量產模式設計
(2,100,000元), PI 2021/5/1~2023/7/31 Advanced BioMed. Inc,奈米薄層流道之試量產製造模式的設計與封裝驗證(I、II), (2,600,000元), PI 2019/9/1~2020/8/31 起元生物科技股份有限公司, OE-AST生物晶片之前臨床研究測試與探討, (1,150,000元), PI 2017/11/1~2021/4/30 Advanced BioMed. Inc, 簡單易製造的奈米薄層流道製造方法之開發(I、II、III), (3,800,000元), PI 2016/12/1~2017/11/31 Advanced
BioMed. Inc, 奈米生物分子提濃晶片之設計與確效(II), (1,200,000元), PI 2015/12/1~2016/11/31 Advanced
BioMed. Inc, 奈米生物分子提濃晶片之設計與確效(I), (1,100,000元), PI 2014/10/25~2015/11/24 Advanced BioMed.
Inc, 試劑濃度梯度產生器之設計與確效, (1,100,000元), PI 臨床醫院合作計畫 2017/1/1~2017/12/31 台中榮總，以念珠菌之出芽生長特性建立可早期偵測念珠菌血症暨鑑定抗藥性之生醫晶片, (500,000元), Co-PI. 2016/1/1-2016/12/31 台中榮總，以生醫晶片平台建立抗藥性細菌偵測系統, (500,000元), Co-PI. 2016/1/1-2016/12/31 台中榮總, 血液中攝護腺腫瘤細胞在根除性攝護腺手術前後的差別與患者臨床表徵之相關性, (500,000
元), Co-PI. 2016/1/1-2016/12/31 台中榮總,快速檢測菌血症相關致病菌生物晶片開發與臨床應用評估,(500,000元), Co-PI. |
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