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Name
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I-Fang Cheng
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Title
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Associate Professor
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Office
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K315-2, K313
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Phone
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886-6-2533131 Ext. 3543
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Email
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ifcheng@stust.edu.tw
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Webpage
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Education
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Ph.D., Institute of Nanotechnology and
Microsystem Engineering, National Cheng Kung University
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Research Interests
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Biomicrofluidic chips, Bio-MEMs/NEMs, Micro/Nano-Electrokinetics,
Biosensors, Research-Product transformation
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Laboratory
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Biomicrofluidics and Bio-Sensing System Lab. (K313)
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Publications
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Journal Papers
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1. E Iswardy, T-C Tsai, I-F
Cheng, T-C Ho, G-C Perng, H-C Chang, A bead-based
immunofluorescence-assay on a microfluidic dielectrophoresis platform for
rapid dengue virus detection, Biosens.
Bioelectron., 95, 174-181 (2017).
(SCI,
IF= 11.44, Ranking: 1/28= 3.5%) (Cited by 61 times)
2. I-F
Cheng*, T-Y Chen, and W-C Chao, Increasing Local Density of
Molecules/Bacteria on a Sensing Surface from Diluted Blood Using 3D Hybrid
Electrokinetics, Biomicrofluidics, 10, 034116 (2016) (SCI,
IF= 3.258, Ranking: 3/31= 9.6%) (Cited by 8 times)
3. I-F Cheng*, W-L Huang, T-Y Chen, Y-D
Lin, C-W Liu, W-C Su*, Antibody-Free Isolation of Rare Cancer Cells from
Blood based on 3D Lateral Dielectrophoresis, Lab Chip, 15, 2950
(2015). (SCI,
IF= 6.97, Ranking: 6/79= 7.5 %) (Cited by 94
times)
(This work was selected for publication as
a Back Cover in Lab Chip)
4. I-F Cheng*, T-Y Chen, R-J Lu and H-W
Wu, Rapid Identification
of Bacteria Utilizing Amplified Dielectrophoretic Force-Assisted
Nanoparticle-Induced SERS, Nanoscale Res Lett, 9, 324
(2014). (SCI, IF= 4.91, Ranking: 24 /143= 16.7 %)
(Cited by 52 times)
5. I-F Cheng, S-C
Chiang, C-C Chung, T-M Yeh, H-C Chang, Ripple Structure-Generated Hybrid
Eelectrokinetics for on-Chip Mixing and Separating of Functionalized Beads,
Biomicrofluidics, 8, 061102 (2014). (SCI,
IF= 3.258, Ranking: 3/31= 9.6%) (Cited
by 9 times)
6. I-F
Cheng*, H-C Chang, T-Y Chen, CM Hu, F-L Yang, Rapid (<5min)
Identification of Pathogen in Human Blood by Electrokinetic Concentration
and Surface-Enhanced Raman Spectroscopy, Scientific Reports(Nature
Publishing Group), 3, 2365 (2013)
(SCI, IF= 5.708, Ranking: 5/56= 8.9%)
(Cited by 154 times)
7. I-F Cheng, S-L Yang, C-C Chung,
H-C Chang, A Rapid Electrochemical Biosensor based on an AC Electrokinetics
Enhanced Immuno-reaction, Analyst, 138, 4656 (2013)
(SCI, IF= 4.616, Ranking:
7/74= 9.4%) (Cited by 36 times)
8. I-F Cheng, H-W Han, H-C Chang, Dielectrophoresis and shear enhanced DNA hybridization for
rapid discrimination of Candida species, Biosens. Bioelectron.,
33, 36 (2012) (SCI,
IF= 11.44, Ranking: 1/28= 3.5%, 3/74= 4%)
9. C-C Chung, I-F Cheng, H-C
Kan, H-M Chen, W-H Yang, H-C Chang, Screening of the antibiotic
susceptibility to ��-lactam-induced elongation of Gram-negative bacteria
based on dielectrophoresis, Anal. Chem., 84, 3347(2012). (SCI, IF= 6.986, Ranking: 4/74= 5%) (Cited by 48 times)
10. I-F Cheng, S-L Liu, C-C Chung, H-C
Chang, Stepwise gray-scale light-induced
electric field gradient for passive and continuous separation of
microparticles, Microfluid Nanofluid, 12, 95 (2012).
(SCI, IF= 2.529, Ranking: 7/56= 12.5%) (Cited by 8 times)
11. S-H Liao†, I-F Cheng† and H-C Chang, Precisely sized
separation of multiple particles based on dielectrophoresis gradient in the
z-direction, Microfluid
Nanofluid, 12, 201 (2012) (†Equal contribution) (SCI, IF= 2.529, Ranking: 7/56= 12.5%) (Cited by 14 times)
12. I-F Cheng, C-C Chung and H-C Chang, High-throughput electrokinetic bioparticle
Focusing based on a travelling-wave dielectrophoretic field, Microfluid Nanofluid, 10,
649 (2011).
(SCI,
IF= 2.529, Ranking: 7/56= 12.5%) (Cited by 36
times)
13. C-C
Chung, I-F Cheng, C-C Lin, and H-C Chang, Rapid
quantification of bio-particles based on image visualisation in a
dielectrophoretic microfluidic chip, Microfluid
Nanofluid, 10, 311 (2011).
(SCI, IF= 2.529, Ranking: 7/56= 12.5%) (Cited by 14 times)
14. I-F
Cheng, C-C Lin, D-Y Lin, H-C Chang, A
dielectrophoretic chip with a roughened metal surface for on-chip Surface
Raman Enhanced Scattering analysis of bacteria, Biomicrofluidics, 4, 034104
(2010).
(SCI, IF= 3.258, Ranking: 3/31= 9.6%) (Cited by 94
times) This work was
also selected for publication in Virtual Journal of Biological
Physics research, Sep. 15 (2010).
15. I-F Cheng, S Senapati, X Cheng, S
Basuray, H-C Chang and H-C Chang, A rapid field-use assay for mismatch number and location
of hybridized DNAs, Lab Chip, 10, 828 (2010). (SCI, IF=
6.97, Ranking: 6/79= 7.5 %)
(Cited by 76 times)
16. I-F
Cheng, V Froude, Y-E Zhu,
H-C Chang and H-C Chang, "A Continuous high throughput
bioparticle sorter based on 3D traveling wave dielectrophoresis", Lab Chip, 9, 3193 (2009). (SCI,
IF= 6.97, Ranking: 6/79= 7.5 %)
(Cited by 163 times)
17. I-F Cheng, H-C Chang, D Hou, and H-C Chang, "An integrated
dielectrophoretic chip for continuous bioparticle filtering, focusing,
trapping and detecting", Biomicrofluidics, 1, 021503 (2007). (SCI,
IF= 3.258, Ranking: 3/31= 9.6%)
(Cited by 311 times, most cited paper in Biomicrofluidics
from 2007 to 2015)
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Conference Papers
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1.I-F Cheng*, T-Y Chen, Y-L Chen, Y-L Chen, W-C Chao,
Rapid Determination of Bacterial Antibiotic ResistanceUsing a
Hybrid
Optofluidic-Electrokinetic Chip , 2018 WorldCongress on Medical Physics and
Biomedical Engineering, Czech Republic, Prague, 2018 (poster presentation)
2.
I-F Cheng*, T-Y Chen, W-C Su, Antibody-FreeIsolation and Analysis of
Circulating Tumor Cells from DilutedHuman Blood, 24th International
Molecular Medicine Tri-Conference(Mol Med TRI-CON2017), (Poster
presentation), USA, San Francisco, 2017 (poster presentation).
3.
I-Fang Cheng*, Tzu-Ying Chen, Minute-level Speed Identification and
Assessment of Bacteria/Cells Using Electrokinetic Assistance, International
Conference on Advanced Technology Innovation 2016(ICATI2016), Bangkok,
Thailand. (Oral presentation)
4.
I-F Cheng*, T-Y Chen, Y-D Lin, C-W Liu, W-C Su, A
NovelDielectrophoresis-Based Microfluidic Chip for Antibody-Free Isolation
of Circulating Tumor Cells from Blood, IEEE NANO 2015, Roma, Italy. (Oral
presentation)
5. I-F Cheng*, T-Y Chen, H-C Chang,
Electrokinetics-Based Microfluidic Technology for the Rapid Separation and
Concentration of Bacteria/Cells/Biomolecules, ICKEM 2014, Indonesia, Bali,
(2014). (Oral
presentation, and session chair)
6. 1. I-F Cheng*, Hsiao-Lan
Yang, Hsien-Chang Chang, (2012) “A Rapid and Label-free Biosensor Based on
an AC Electrokinetically-Enhanced Immuno-reaction”, IEEE NANOMED2012,
Bangkok, Thailand. (Oral presentation)
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Projects
NSTC Projects:
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Year
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Project
Title
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Budget
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Period
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2022
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Development of a Clinical Instrument for Pure Culture-free
Antibiotics Susceptibility Testing (II) (Advanced application for incubating industry project)
(NSTC 111-2622-B-218-001) PI
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9,800,000
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2022/1/1 – 2023/5/31
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2022
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Development of large-area,
multiscale nanostructure polymer molding technology and its applications in
biomedical and optical engineering
(NSTC 111-2622-B-218-001) Co-PI
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6,000,000
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2022/8/1 –
2023/7/31
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2020
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Development
of a Biochip System to Accelerate Total Assay Time For Precision Medicine
in Clinical Sepsis
(MOST
109-2221-E-492-002-MY2) PI
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2,469,000
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2020/8/1 –
2022/10/31
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2020
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Development
of a Clinical Instrument for Pure Culture-free Antibiotics Susceptibility
Testing (I) (Advanced application for incubating industry
project)
(MOST
109-2622-B-492-002-) PI
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9,200,000
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2020/11/1
– 2021/12/31
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2020
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Label-free, rapid, high-sensitivity optofluidic
biosensing system for rapid and simultaneous identification of pathogens
and host response in septic patients (MOST 109-2218-E-194-006-) Co-PI
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4,488,000
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2020/5/1–
2021/4/30
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2019
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Development
of a Cost-Effective BioChip System for Rapid and On-Site Detection of
Bacteria Cell Density, Somatic Cell Count, and Antimicrobial Susceptibility
Testing (MOST 108-2221-E-492-008-) PI
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991,000
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2019/8/1–
2020/7/31
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2019
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Label-free, rapid,
high-sensitivity optofluidic biosensing system for rapid and simultaneous
identification of pathogens and host response in septic patients (III) (MOST 108-2218-E-194-001) Co-PI
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6,303,000
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2019/5/1–
2020/4/30
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2018
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Label-free, rapid, high-sensitivity optofluidic
biosensing system for rapid and simultaneous identification of pathogens
and host response in septic patients
(II) (MOST 107-2218-E-194-004) Co-PI
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6,540,000
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2018/5/1–
2019/4/30
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2018
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Development
of a biomicrofluidic chip and its portable prototype for rapid detection of
Mastitis, analysis of bacterial antibiotic susceptibility, and milk quality
monitoring (MOST
107-2221-E-492-020-) PI
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1,136,000
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2018/8/1–
2019/7/31
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2017
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Label-free, rapid, high-sensitivity optofluidic
biosensing system for rapid and simultaneous identification of pathogens
and host response in septic patients
(I) (MOST 106-3114-E-194-001) Co-PI
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6,873,000
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2017/5/1–
2018/4/30
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2016
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Rapid
identification and quantification of pathogens form blood/water and
determination of its Drug Susceptibility within four hours
(MOST 105-2628-E-492 -001 -MY2) (Excellent Young Scholars
project) PI
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2,423,000
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2016/8/1–
2018/10/31
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2015
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Development of Antibody-free Isolation and Analysis
of Circulating Tumor Cells for Early Detection, Therapy Monitoring and
Prognosis of Lung Cancer (MOST
104-2221-E-492 -009 -MY2)
PI
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1,690,000
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2015/8/1–
2017/10/31
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2014
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An AC Electrokinetics-based Micro-Analysis System for
Sorting, Trapping Cancer Cells and Discriminating their Drug
Susceptibilities
(NSC 102-2221-E-492 -001 -MY2) (Excellent Young Scholars
project) PI
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1,861,000
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2013/8/1–
2015/10/31
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2013
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AC
Electrokinetic Concentration of Pathogen from Blood for Surface Enhanced
Raman Spectroscopy Identification of Bacteria (NSC
101-2218-E-492-002-) PI
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686,000
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2012/8/1–
2013/7/31
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Industry
Projects:
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Year
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Project
Title
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Budget
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Period
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2022
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BioMicrofluidic chip
fabrication, real sample validation, and the design for pre-production
tests (PI)
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2,100,000
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2022/12/20 -
2024/12/19
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2021
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Design and
Verification for Pilot Run of Thin-layer nano-channel Fabrication (I、II) (PI)
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2,600,000
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2021/05/01 -2023/7/31
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2018
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OE-AST Biochip on Clinical Testing and
Investigation (PI)
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1,150,000
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2007/06/01 - 2008/05/31
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2017
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Development of a simple method for thin-layer
nano-channel fabrication (I、II、III) (PI)
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3,800,000
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2017/12/01 - 2021/3/30
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2016
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The Design and
Validation of a Microfluidic
Chip for Nanoscale Biomolecular Concentration (II) (PI)
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1,200,000
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2016/11/01 - 2017/11/30
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2015
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The Design and
Validation of a Microfluidic
Chip for Nanoscale Biomolecular Concentration (I) (PI)
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1,100,000
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2015/10/01 - 2016/9/30
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2014
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The Design and Validation for a Reagent
Concentration Gradient Generator
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1,100,000
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2014/10/01 - 2015/9/30
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Patents
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1. Photoelectrical device for concentration
detection, method for concentration detection thereof and method for
testing an antibiotic susceptibility on bacteria, I-Fang Cheng , I-L Chen, T-Y Chen, US patent, Patent
NO.: US 11,143,585 B2, 2021-2039.。
2. 一種用於濃度檢測的光電裝置及其濃度檢測方法以及測試藥物對細菌有效性的方法，發明人: 鄭宜肪、陳姿穎、陳以靈，中華民國專利，專利證號: I685656，2020-2038。
3. 分離粒子之方法、其流道裝置以及捕捉結構，發明人: 鄭宜肪、蘇五洲、黃偉倫、陳姿穎、林育德，中華民國專利，專利證號: I524930, 2016-2033。
4.
‘Bio-Chip
and Method for Separating and Concentrating Particles Using the Same,’, I-Fang
Cheng, Hsien-Chang Chang, Fu-Liang Yang, Tzu-Ying Chen, US Patent,
US 9,498,784 B2, 2016-2035.
5.
以複合電動力捕捉並分析生物微粒的方法與晶片，發明人: 鄭宜肪、張憲彰、蘇五洲、黃偉倫，中華民國專利，專利證號: I494563, 2015-2033.
6. 可選擇地濃縮分離待測粒子的方法與晶片，發明人: 鄭宜肪、楊富量、張憲彰、陳姿穎，中華民國專利，專利證號: I510773 , 2015-2032.
7.
生物晶片裝置及分離並濃縮一流體中的微粒的方法，發明人: 鄭宜肪、楊富量、張憲彰、陳姿穎，中華民國專利，專利證號: I472756, 2015-2032.
8.
介電微粒操控晶片與其製造方法和操控介電微粒的方法,發明人: 張憲彰、鍾政哲、鄭宜肪、王竣宏、蔣盛泉、任麗青，專利證號: I507803，2015-2033。
9.
Method
for Antibiotic Susceptibility Testing and Determining Minimum Inhibitory
Concentration of the Antibiotics, Cheng-Che Chung, I-Fang Cheng, Hsien-Chang Chang, US Patent, US 8,911,605
B2, 2014.
10.
Microbial
Identification and Manipulation of Nanoscale Biomolecules, I-Fang
Cheng, Hsien-Chang Chang, Cheng-Che Chung, US Patent, US 8,808,518,
2014-2034.
11.
生物鑑定方法與操控奈米等級之生物分子的方法，發明人：鄭宜肪、張憲彰、鍾政哲，中華民國專利，專利證號: I404802 , 2013~2030.
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